The biochemical utility of chromogranin A, chromogranin B and cocaine- and amphetamine-regulated transcript for neuroendocrine neoplasia
نویسندگان
چکیده
منابع مشابه
Quantifying the effects of renal impairment on plasma concentrations of the neuroendocrine neoplasia biomarkers chromogranin A, chromogranin B, and cocaine- and amphetamine-regulated transcript.
Neuroendocrine neoplasia (NEN) accounts for 2% of all malignancies (1 ). Patients with NEN often present with nonspecific symptoms and thus represent a major diagnostic challenge. There are several circulating NEN biomarkers, and chromogranin A (CgA) is regarded as the gold standard (2 ). Chromogranin B (CgB) has been found to be a useful diagnostic addition to CgA measurements (3 ). The peptid...
متن کاملComparison of the utility of Cocaine- and Amphetamine-Regulated Transcript (CART), chromogranin A, and chromogranin B in neuroendocrine tumor diagnosis and assessment of disease progression.
CONTEXT Prognosis in patients with neuroendocrine tumors (NETs) is often poor, frequently reflecting delayed diagnosis. Hence, accurate and practical NET markers are needed. Cocaine- and amphetamine-regulated transcript (CART) peptide is a potential novel NET marker. DESIGN AND PARTICIPANTS Circulating levels of CART peptide and the established NET markers chromogranin A (CgA) and chromograni...
متن کاملQuantifying the Effects of Renal Impairment on Plasma Concentrations of the Neuroendocrine Neoplasia Biomarkers Chromogranin A, Chromogranin B, and Cocaine- and Amphetamine-Regulated
Neuroendocrine neoplasia (NEN) accounts for 2% of all malignancies (1 ). Patients with NEN often present with nonspecific symptoms and thus represent a major diagnostic challenge. There are several circulating NEN biomarkers, and chromogranin A (CgA) is regarded as the gold standard (2 ). Chromogranin B (CgB) has been found to be a useful diagnostic addition to CgA measurements (3 ). The peptid...
متن کاملCocaine- and amphetamine-regulated transcript in neuroendocrine tumors.
BACKGROUND/AIMS Cocaine- and amphetamine-regulated transcript (CART) is an anorexigenic regulatory peptide highly expressed in the brain's appetite control centers, but also in peripheral neurons and in endocrine cells in the adrenal medulla, thyroid, pancreatic islets, and in the gastrointestinal tract. Plasma levels of CART were recently shown to be elevated in patients with neuroendocrine tu...
متن کامل[Chromogranin A and neuroendocrine tumors].
Chromogranin A (CgA) is the most abundant granin in gastroenteropancreatic neuroendocrine tumors (GEP-NETs). As a tumor marker is moderately sensitive and nonspecific. Despite the limitations of testing methods, which require careful interpretation, especially in the case of gastrinomas, patients treated with somatostatin analogues, and poorly differentiated tumors, it is the best tumor marker ...
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ژورنال
عنوان ژورنال: Annals of Clinical Biochemistry: International Journal of Laboratory Medicine
سال: 2013
ISSN: 0004-5632,1758-1001
DOI: 10.1177/0004563213489670